CHRM2, cholinergic receptor muscarinic 2, 1129

N. diseases: 91; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 AlteredExpression disease BEFREE Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins. 16181410 2005
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 AlteredExpression disease LHGDN Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins. 16181410 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.020 AlteredExpression disease BEFREE One immunological component of asthma is believed to be the interaction of eosinophils with parasympathetic cholinergic nerves and a consequent inhibition of acetylcholine muscarinic M2 receptor activity, leading to enhanced acetylcholine release and bronchoconstriction. 12948933 2003
CUI: C0018801
Disease: Heart failure
Heart failure 		0.010 AlteredExpression disease BEFREE The ghrelin receptor is a seven-transmembrane (7-TM) receptor known to have an increased level of expression in human carcinoma and heart failure. 30282322 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.010 AlteredExpression disease BEFREE The ghrelin receptor is a seven-transmembrane (7-TM) receptor known to have an increased level of expression in human carcinoma and heart failure. 30282322 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.010 AlteredExpression group BEFREE The overexpression of Kcnq1, Crlf1, Alb and Xirp1 and the inhibition of Galr2, Kcnh1, Ache, Chrm2 and Slc5a7 expression may indicate that a relationship exists between these genes and the cause and/or worsening of hypertension in SHR and SHRSP. 30882592 2019
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
Benign Prostatic Hyperplasia 		0.010 AlteredExpression disease BEFREE We analyzed bladder specimens from 43 patients with obstructive BPH undergoing transurethral resection of the prostate as compared to 10 age-matched controls with an International Prostatic Symptom Score of <8 and a prostate volume of <30 g. A bladder biopsy was performed for relative gene expression analysis with quantitative real-time polymerase chain reaction of collagens I and III, MMP-1, MMP-2, and MMP-9; tissue inhibitors of metalloproteinases (TIMPs) TIMP-1, TIMP-2, and reversion-inducing cysteine-rich protein with kazal motifs (RECK); CHRM2 and CHRM3; VEGF and CD105; and NGF and nerve growth factor receptor (NGFr). 28506859 2017
CUI: C0005697
Disease: Neurogenic Urinary Bladder
Neurogenic Urinary Bladder 		0.310 Therapeutic disease CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies 		0.300 Therapeutic group CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0149622
Disease: Neurogenic Urinary Bladder, Atonic
Neurogenic Urinary Bladder, Atonic 		0.300 Therapeutic phenotype CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0271673
Disease: Symmetric Diabetic Proximal Motor Neuropathy
Symmetric Diabetic Proximal Motor Neuropathy 		0.300 Therapeutic disease CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0271674
Disease: Asymmetric Diabetic Proximal Motor Neuropathy
Asymmetric Diabetic Proximal Motor Neuropathy 		0.300 Therapeutic disease CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0271678
Disease: Diabetic Mononeuropathy
Diabetic Mononeuropathy 		0.300 Therapeutic disease CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0271680
Disease: Diabetic Polyneuropathies
Diabetic Polyneuropathies 		0.300 Therapeutic group CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0271685
Disease: Diabetic Amyotrophy
Diabetic Amyotrophy 		0.300 Therapeutic disease CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0271686
Disease: Diabetic Autonomic Neuropathy
Diabetic Autonomic Neuropathy 		0.300 Therapeutic disease CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0392115
Disease: Neurogenic Urinary Bladder, Uninhibited
Neurogenic Urinary Bladder, Uninhibited 		0.300 Therapeutic disease CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0393835
Disease: Diabetic Asymmetric Polyneuropathy
Diabetic Asymmetric Polyneuropathy 		0.300 Therapeutic disease CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0750953
Disease: Urinary Bladder Neurogenesis
Urinary Bladder Neurogenesis 		0.300 Therapeutic phenotype CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0750955
Disease: Neurogenic Urinary Bladder, Spastic
Neurogenic Urinary Bladder, Spastic 		0.300 Therapeutic phenotype CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0751074
Disease: Diabetic Neuralgia
Diabetic Neuralgia 		0.300 Therapeutic disease CTD_human The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder. 20624991 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.540 Biomarker disease PSYGENET Genetic variation in the cholinergic muscarinic-2 (M(2)) receptor gene (CHRM2) has been associated with the risk for developing depression. 20351719 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.540 Biomarker disease BEFREE These results are consistent with a gender-specific role of the CHRM2 gene in depression in women. 12116189 2002
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.540 Biomarker disease PSYGENET In this study, we evaluated whether genetic variation in the CHRM2 gene is also a risk factor for the correlated clinical characteristics of alcoholism and depression. 15229186 2004
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.540 Biomarker disease PSYGENET These results are consistent with a gender-specific role of the CHRM2 gene in depression in women. 12116189 2002